Exosomal MicroRNAs Released by Activated Astrocytes as Potential Neuroinflammatory Biomarkers.

ABSTRACT: Neuroinflammation is a hallmark of several neurodegenerative diseases and disorders, including traumatic brain injury (TBI). Neuroinflammation results in the activation of glial cells which exacerbates the neuroinflammatory process by secretion of pro-inflammatory cytokines and results in disruption of glial transmission networks. The glial cells, including astrocytes, play a critical role in the maintenance of homeostasis in the brain. Activated astrocytes release several factors as part of the inflammatory process including cytokines, proteins, and microRNAs (miRNAs). MiRNAs are noncoding RNA molecules involved in normal physiological processes and disease pathogenesis. MiRNAs have been implicated as important cell signaling molecules, and they are potential diagnostic biomarkers and the

SUBMITTER: Gayen M 

PROVIDER: S-EPMC7177648 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature