CircHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family.

ABSTRACT: Circular RNA (circRNA), as a kind of novel identified non-coding RNA, has become the focus of attention for its vital physiological and pathological roles. However, the function and mechanism of circRNAs in the regulation of cancer progression are largely unknown. In the present study we found a circRNA termed circHMCU whose expression was associated with poor prognosis. It was upregulated in cell lines with high metastatic potential compared with its parental cell line and in breast cancer tissues compared with normal tissues. In vitro results proved that circHMCU could significantly promote proliferation, migration, and invasion abilities of breast cancer cells via affecting the G₁ phase cell cycle checkpoint and the epithelial-mesenchymal transition (EMT) pathway. Further in 

SUBMITTER: Song X 

PROVIDER: S-EPMC7178009 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature