Ontology highlight
ABSTRACT:
SUBMITTER: Alam H
PROVIDER: S-EPMC7178078 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Alam Hunain H Tang Ming M Maitituoheti Mayinuer M Dhar Shilpa S SS Kumar Manish M Han Chae Young CY Ambati Chandrashekar R CR Amin Samir B SB Gu Bingnan B Chen Tsai-Yu TY Lin Yu-Hsi YH Chen Jichao J Muller Florian L FL Putluri Nagireddy N Flores Elsa R ER DeMayo Francesco J FJ Baseler Laura L Rai Kunal K Lee Min Gyu MG
Cancer cell 20200402 4
Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a COMPASS-like enzyme, also called MLL4) is among the most highly inactivated epigenetic modifiers in lung cancer. Here, we show that lung-specific loss of Kmt2d promotes lung tumorigenesis in mice and upregulates pro-tumorigenic programs, including glycolysis. Pharmacological inhibition of glycolysis preferentially impedes ...[more]