Dual-Function Antibacterial Micelle via Self-Assembling Block Copolymers with Various Antibacterial Nanoparticles.

ABSTRACT: Antibacterial biomaterials with kill-resist dual functions by combining multiple active components have been constructed, with a final aim at decreasing the incidence of biomaterial-centered infection. Self-assemblies of bactericidal ZnO or Ag-ZnO nanoparticles (NPs) with triblock copolymers, poly(ethylene glycol)-b-poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-poly(ethylene glycol) (PEG-PHBV-PEG), showed a hydrophobic PHBV layer on NPs with PEG segments exposed outside via hydrogen bonding, resulting in long PEG (M _w = 2000) aggregation and short PEG (M _w = 1000) aggregation, respectively. These nanocomposite aggregations released ZnO or Ag-ZnO rapidly within initial few hours, and about 42-45% of NPs were left in the nanocomposites

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC7178363 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature