InterPep2: global peptide-protein docking using interaction surface templates.

ABSTRACT:

Motivation

Interactions between proteins and peptides or peptide-like intrinsically disordered regions are involved in many important biological processes, such as gene expression and cell life-cycle regulation. Experimentally determining the structure of such interactions is time-consuming and difficult because of the inherent flexibility of the peptide ligand. Although several prediction-methods exist, most are limited in performance or availability.

Results

InterPep2 is a freely available method for predicting the structure of peptide-protein interactions. Improved performance is obtained by using templates from both peptide-protein and regular protein-protein interactions, and by a random forest trained to predict the DockQ-score for a given template using sequence and s

SUBMITTER: Johansson-Akhe I 

PROVIDER: S-EPMC7178396 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature