GlyMDB: Glycan Microarray Database and analysis toolset.

ABSTRACT:

Motivation

Glycan microarrays are capable of illuminating the interactions of glycan-binding proteins (GBPs) against hundreds of defined glycan structures, and have revolutionized the investigations of protein-carbohydrate interactions underlying numerous critical biological activities. However, it is difficult to interpret microarray data and identify structural determinants promoting glycan binding to glycan-binding proteins due to the ambiguity in microarray fluorescence intensity and complexity in branched glycan structures. To facilitate analysis of glycan microarray data alongside protein structure, we have built the Glycan Microarray Database (GlyMDB), a web-based resource including a searchable database of glycan microarray samples and a toolset for data/structure analysis.

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7178435 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature