NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice.

ABSTRACT:

Background

Depression is a common mental disease that mainly manifests as bad mood, decreased interest, pessimism, slow thinking, lack of initiative, poor diet and sleep. Patients with severe depression have suicidal tendencies. Exosomes are small vesicles released by the fusion of a multivesicular body and membranes, and they contain specific proteins, nucleic acids, and lipids related to the cells from which they originate. MicroRNAs (miRNAs) are 20-24 nt RNAs that can be packaged into exosomes and can play important regulatory roles. Astrocytes are the most abundant cell population in the central nervous system and have a close link to depression. Astrocyte activation could result in the release of inflammatory cytokines, including IL-1β, IL-6, and TNF-α, which could promote the

SUBMITTER: Li D 

PROVIDER: S-EPMC7178582 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature