The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits.

ABSTRACT:

Background

Hair follicles are an appendage of the vertebrate epithelium in the skin that arise from the embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) are the key dermal component of the hair follicle that directly regulate hair follicle development, growth and regeneration. According to recent studies, miRNAs play an important role in regulating hair follicle morphogenesis and the proliferation, differentiation and apoptosis of hair follicle stem cells.

Results

The miRNA expression profile of the DPCs from Rex rabbits with different hair densities revealed 240 differentially expressed miRNAs (|log₂(HD/LD)| > 1.00 and Q-value≤0.001). Among them, ocu-miR-205-5p was expressed at higher levels in DPCs from rabbits with low

SUBMITTER: Liu G 

PROVIDER: S-EPMC7178635 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature