Sex-dependent effects of ambient PM_2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice.

ABSTRACT:

Background & aims

Emerging evidence supports ambient fine particulate matter (PM_2.5) exposure is associated with insulin resistance (IR) and hepatic lipid accumulation. In this study, we aimed to evaluate the sex-dependent vulnerability in response to PM_2.5 exposure and investigate the underlying mechanism by which PM_2.5 modulates hepatic lipid metabolism.

Methods

Both male and female C57BL/6 mice were randomly assigned to ambient PM_2.5 or filtered air for 24 weeks via a whole body exposure system. High-coverage quantitative lipidomics approaches and liquid chromatography-mass spectrometry techniques were performed to measure hepatic metabolites and hormones in plasma. Metabolic studies, histological analyses, as well as gene expre

SUBMITTER: Li R 

PROVIDER: S-EPMC7178763 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature