DeepSuccinylSite: a deep learning based approach for protein succinylation site prediction.

ABSTRACT:

Background

Protein succinylation has recently emerged as an important and common post-translation modification (PTM) that occurs on lysine residues. Succinylation is notable both in its size (e.g., at 100 Da, it is one of the larger chemical PTMs) and in its ability to modify the net charge of the modified lysine residue from + 1 to - 1 at physiological pH. The gross local changes that occur in proteins upon succinylation have been shown to correspond with changes in gene activity and to be perturbed by defects in the citric acid cycle. These observations, together with the fact that succinate is generated as a metabolic intermediate during cellular respiration, have led to suggestions that protein succinylation may play a role in the interaction between cellular metabolism and imp

SUBMITTER: Thapa N 

PROVIDER: S-EPMC7178942 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature