MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia.

ABSTRACT:

Background

In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. Members of the LPA family are potent lipid mediators transmitting signals via six different G protein-coupled LPA receptors (LPAR1-6). The LPA signaling axis is indispensable for brain development and function of the nervous system; however, during damage of the central nervous system, LPA levels can increase and aberrant signaling events counteract brain function. Here, we investigated regulation of the ATX/LPA/LPAR axis in response to lipopolysaccharide-induced systemic inflammation in mice and potential neurotoxic polarization programs in LPA-activated primary murine microglia.

Methods

In vivo, LPAR1-6 expre

SUBMITTER: Plastira I 

PROVIDER: S-EPMC7178949 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature