MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease.

ABSTRACT:

Background

Environmental organic dust exposures enriched in Toll-like receptor (TLR) agonists can reduce allergic asthma development but are associated with occupational asthma and chronic bronchitis. The TLR adaptor protein myeloid differentiation factor88 (MyD88) is fundamental in regulating acute inflammatory responses to organic dust extract (ODE), yet its role in repetitive exposures is unknown and could inform future strategies.

Methods

Wild-type (WT) and MyD88 knockout (KO) mice were exposed intranasally to ODE or saline daily for 3 weeks (repetitive exposure). Repetitively exposed animals were also subsequently rested with no treatments for 4 weeks followed by single rechallenge with saline/ODE.

Results

Repetitive ODE exposure induced neutrophil influx and rel

SUBMITTER: Johnson AN 

PROVIDER: S-EPMC7178993 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature