Nickel-Catalyzed Conversion of Enol Triflates into Alkenyl Halides.

ABSTRACT: A Ni-catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench-stable Ni(OAc)₂ ⋅4 H₂ O as a precatalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either 1,5-cyclooctadiene or 4-(N,N-dimethylamino)pyridine.

SUBMITTER: Hofstra JL 

PROVIDER: S-EPMC7179072 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature