Ontology highlight
ABSTRACT:
SUBMITTER: Mulfaul K
PROVIDER: S-EPMC7179253 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell reports 20200201 7
Retinal degeneration is a form of neurodegenerative disease and is the leading cause of vision loss globally. The Toll-like receptors (TLRs) are primary components of the innate immune system involved in signal transduction. Here we show that TLR2 induces complement factors C3 and CFB, the common and rate-limiting factors of the alternative pathway in both retinal pigment epithelial (RPE) cells and mononuclear phagocytes. Neutralization of TLR2 reduces opsonizing fragments of C3 in the outer ret ...[more]