Comparison of early-stage changes of osteoarthritis in cartilage and subchondral bone between two different rat models.

ABSTRACT: Osteoarthritis (OA) is a chronic degenerative joint disease and the major cause of joint pain and disability in the elderly. It is mainly characterized by articular cartilage degradation and subchondral bone remodeling. There are two main types of OA: natural occurring OA and secondary OA, mainly associated with aging and trauma, respectively. In this study, we established two OA models in rat knee joints to simulate the two types of OA, using the type II collagenase injection (CI) and anterior cruciate ligament transection (ACLT), respectively. After intervention for 2-6 weeks, cartilage and subchondral bone changes were detected in histological staining, immunochemistry, and micro-CT. Results showed that both models with typical pathology changes of OA were successfully induced, while th

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7179570 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature