Antibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function.

ABSTRACT: Antibiotics revolutionized the treatment of infectious diseases; however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host's microbiome. The microbiome plays a key role in human health, and its perturbation is increasingly recognized as contributing to many human diseases. Widespread broad-spectrum antibiotic use has also resulted in the emergence of multidrug-resistant pathogens, spurring the development of pathogen-specific strategies such as monoclonal antibodies (MAbs) to combat bacterial infection. Not only are pathogen-specific approaches not expected to induce resistance in nontargeted bacteria, but they are hypothesized to have minimal impact on the gut microbiome. Here, we compare the effects of antibiotics, pathogen-specific MAbs, and

SUBMITTER: Jones-Nelson O 

PROVIDER: S-EPMC7179586 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature