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Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada.

ABSTRACT: A strain of extensively drug-resistant (XDR) Salmonella enterica serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (n?=?9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatment with carbapenems or azithromycin in suspected typhoid cases with travel history to Pakistan.

SUBMITTER: Eshaghi A 

PROVIDER: S-EPMC7179602 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada.

Eshaghi Alireza A   Zittermann Sandra S   Bharat Amrita A   Mulvey Michael R MR   Allen Vanessa G VG   Patel Samir N SN  

Antimicrobial agents and chemotherapy 20200421 5

A strain of extensively drug-resistant (XDR) <i>Salmonella enterica</i> serovar Typhi has caused a large ongoing outbreak in Pakistan since 2016. In Ontario, Canada, 10 cases of mainly bloodstream infections (<i>n</i> = 9) were identified in patients who traveled to Pakistan. Whole-genome sequencing showed that Canadian cases were genetically related to the Pakistan outbreak strain. The appearance of XDR typhoid cases in Ontario prompted a provincial wide alert to physicians to recommend treatme  ...[more]

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