Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells.

ABSTRACT: Pathogen-initiated chronic inflammation or autoimmune diseases accelerate proliferation and promote differentiation of hematopoietic stem cells (HSCs) but simultaneously reduce reconstitution capacity. Nevertheless, the effect of acute infection and inflammation on functional HSCs is still largely unknown. Here we found that acute infection elicited by heat-inactivated Escherichia coli (HIEC) expanded bone marrow lineage-negative (Lin)^- stem-cell antigen 1 (Sca-1)⁺cKit⁺ (LSK) cell population, leading to reduced frequency of functional HSCs in LSK population. However, the total number of BM phenotypic HSCs (Flk2^-CD48^-CD150⁺ LSK cells) was not altered in HIEC-challenged mice. Additionally, the reconstitution capacity of

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7179742 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature