NT-proBNP, race and endothelial function in the Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Objective

Natriuretic peptides (NPs) are hormones with cardioprotective effects. NP levels vary by race; however, the pathophysiological consequences of lower NP levels are not well understood. We aimed to quantify the association between NPs and endothelial function as measured by flow-mediated dilation (FMD) and the contribution of NP levels to racial differences in endothelial function.

Methods

In this cross-sectional study of 2938 Multi-Ethnic Study of Atherosclerosis participants (34% Caucasian, 20% African-American, 20% Asian-American and 26% Hispanic) without cardiovascular disease at baseline, multivariable linear regression models were used to examine the association between serum N-terminal pro-B-type NP (NT-proBNP) and natural log-transformed FMD. We also tested w

SUBMITTER: Yang S 

PROVIDER: S-EPMC7179817 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature