Clinical MEN-1 Among a Large Cohort of Patients With Acromegaly.

ABSTRACT: Clinical multiple endocrine neoplasia type 1 (MEN-1) is diagnosed by the presence of at least 2 MEN-1-associated tumors. Many patients with acromegaly and clinical MEN-1 yield negative testing for MEN1 mutations. While cases of acromegaly and primary hyperparathyroidism (PHP) with negative genetic testing have been reported, its prevalence among patients with acromegaly is undetermined, and the clinical presentation has not been well characterized. The main goals of this study are: (1) To determine the prevalence of clinical MEN-1 with PHP in patients with acromegaly and characterize their clinical features; and (2) to evaluate the genetic basis for the coexistence of acromegaly and PHP. Retrospective record review and genetic analysis. Clinical Research Centers. 414 patients with acromega

SUBMITTER: Nachtigall LB 

PROVIDER: S-EPMC7180000 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature