Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1.

ABSTRACT:

Objective

Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular dysfunction in cardiovascular disease and represent therapeutic targets in cardiovascular prevention. The object of this study was to define the platelet phenotype and effector cell properties on vascular health in psoriasis and evaluate whether aspirin modulates the platelet-induced phenotype. Approach and Results: Platelets from psoriasis patients (n=45) exhibited increased platelet activation (relative to age- and gender-matched controls, n=18), which correlated with psoriasis skin severity. Isolated platelets from psoriasis patients demonstrated a 2- to 3-fold (P<0.01) increased adhesion to human aortic endo

SUBMITTER: Garshick MS 

PROVIDER: S-EPMC7180109 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature