Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging.

ABSTRACT:

Purpose

To evaluate the complex fiber orientations and 3D collagen fiber network of knee joint connective tissues, including ligaments, muscle, articular cartilage, and meniscus using high spatial and angular resolution diffusion imaging.

Methods

Two rat knee joints were scanned using a modified 3D diffusion-weighted spin echo pulse sequence with the isotropic spatial resolution of 45 μm at 9.4T. The b values varied from 250 to 1250 s/mm² with 31 diffusion encoding directions for 1 rat knee. The b value was fixed to 1000 s/mm² with 147 diffusion encoding directions for the second knee. Both the diffusion tensor imaging (DTI) model and generalized Q-sampling imaging (GQI) method were used to investigate the fiber orientation distributions and tractograph

SUBMITTER: Wang N 

PROVIDER: S-EPMC7180110 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature