Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.

ABSTRACT:

Objective

This study aimed to test the hypothesis that young adults with obesity and cold-activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold-activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but they have acknowledged that the clinical implications of these findings remain uncertain.

Methods

Twenty-one females and twenty-three males with obesity (BMI ≥ 30 kg/m² ) underwent a 2-hour cooling protocol before ¹⁸ F-fluorodeoxyglucose (¹⁸ F-FDG)-positron emission tomography/x-ray computed tomography scan to determine the prevalence, volume, and ¹⁸ F-FDG uptake o

SUBMITTER: Mihalopoulos NL 

PROVIDER: S-EPMC7180112 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature