Drug-Induced Resistance in Micrometastases: Analysis of Spatio-Temporal Cell Lineages.

ABSTRACT: Resistance to anti-cancer drugs is a major cause of treatment failure. While several intracellular mechanisms of resistance have been postulated, the role of extrinsic factors in the development of resistance in individual tumor cells is still not fully understood. Here we used a hybrid agent-based model to investigate how sensitive tumor cells develop drug resistance in the heterogeneous tumor microenvironment. We characterized the spatio-temporal evolution of lineages of the resistant cells and examined how resistance at the single-cell level contributes to the overall tumor resistance. We also developed new methods to track tumor cell adaptation, to trace cell viability trajectories and to examine the three-dimensional spatio-temporal lineage trees. Our findings indicate that drug-induc

SUBMITTER: Perez-Velazquez J 

PROVIDER: S-EPMC7180185 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature