Adaptation within embryonic and neonatal heart environment reveals alternative fates for adult c-kit⁺ cardiac interstitial cells.

ABSTRACT: Cardiac interstitial cells (CICs) perform essential roles in myocardial biology through preservation of homeostasis as well as response to injury or stress. Studies of murine CIC biology reveal remarkable plasticity in terms of transcriptional reprogramming and ploidy state with important implications for function. Despite over a decade of characterization and in vivo utilization of adult c-Kit⁺ CIC (cCIC), adaptability and functional responses upon delivery to adult mammalian hearts remain poorly understood. Limitations of characterizing cCIC biology following in vitro expansion and adoptive transfer into the adult heart were circumvented by delivery of the donated cells into early cardiogenic environments of embryonic, fetal, and early postnatal developing hearts. These three

SUBMITTER: Wang BJ 

PROVIDER: S-EPMC7180292 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature