Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma.

ABSTRACT:

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Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of cells with stem cell features (cancer stem cells; CSCs). CSCs are considered a pivotal target for the eradication of cancer, and liver CSCs have been identified by the use of various stem cell markers. However, little information is known about the expression patterns and characteristics of marker-positive CSCs, hampering the development of personalized CSC-targeted therapy. Here, we show that CSC markers EpCAM and CD90 are independently expressed in liver cancer. In primary HCC, EpCAM+ and CD90+ cells resided distinctively, and gene-expression analysis of sorted cells suggested that EpCAM+ cells had features of epithelial cells, whereas CD90+ cells had those of vascular endothelial

SUBMITTER: Yamashita T 

PROVIDER: S-EPMC7180389 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature