Clinical importance of VEGFC and PD-L1 co-expression in lung adenocarcinoma patients.

ABSTRACT:

Background

Vascular endothelial growth factor C (VEGFC), an activator of lymphangiogenesis, is newly identified as an immunomodulator which can regulate the immune system so that tumor cells more easily escape immune surveillance. Evidence has shown programmed cell death-ligand 1 (PD-L1) can also suppress the immune response. Nevertheless, the clinical significance of co-expression of VEGFC and PD-L1 for predicting outcomes in patients with lung adenocarcinoma has not yet been determined.

Methods

A total of 114 patients with lung adenocarcinoma who underwent surgeries at Tianjin Medical University Cancer Institute and Hospital between December 2011 and September 2016 were retrospectively reviewed. Tissue specimens were collected for immunohistochemistry of VEGFC and PD-L1 wh

SUBMITTER: Qin T 

PROVIDER: S-EPMC7180596 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature