Drugs with new lease of life as quorum sensing inhibitors: for combating MDR Acinetobacter baumannii infections.

ABSTRACT: The emergence of multidrug-resistant (MDR) strains is a major health problem worldwide. There is an urgent need for novel strategies to combat bacterial infections caused by MDR strains like Pseudomonas aeruginosa and Acinetobacter baumannii. Quorum sensing (QS) is a critical communication system in bacterial community controlling survival and virulence. The awareness of the importance of QS in bacterial infections has stimulated research to identify QS inhibitors (QSIs) to defeat microbes. In this study, four FDA-approved drugs (besides azithromycin as positive QSI) were tested for potential QS inhibition against clinical A. baumannii isolates and P. aeruginosa (PAO1) standard strain. The inhibitory effect of these drugs on virulence factors of both microbes has been investigated. The stu

SUBMITTER: Seleem NM 

PROVIDER: S-EPMC7180647 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature