New Substituted Benzoylthiourea Derivatives: From Design to Antimicrobial Applications.

ABSTRACT: The increasing threat of antimicrobial resistance to all currently available therapeutic agents has urged the development of novel antimicrobials. In this context, a series of new benzoylthiourea derivatives substituted with one or more fluorine atoms and with the trifluoromethyl group have been tested, synthesized, and characterized by IR, NMR, CHNS and crystal X-ray diffraction. The molecular docking has provided information regarding the binding affinity and the orientation of the new compounds to Escherichia coli DNA gyrase B. The docking score predicted the antimicrobial activity of the studied compounds, especially against E. coli, which was further demonstrated experimentally against planktonic and biofilm embedded bacterial and fungal cells. The compounds bearing one

SUBMITTER: Limban C 

PROVIDER: S-EPMC7180980 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature