Formulation and Optimization of Nanoemulsions Using the Natural Surfactant Saponin from Quillaja Bark.

ABSTRACT: Replacing synthetic surfactants by natural alternatives when formulating nanoemulsions has gained attention as a sustainable approach. In this context, nanoemulsions based on sweet almond oil and stabilized by saponin from Quillaja bark with glycerol as cosurfactant were prepared by the high-pressure homogenization method. The effects of oil/water (O/W) ratio, total surfactant amount, and saponin/glycerol ratio on their stability were analyzed. The formation and stabilization of the oil-in-water nanoemulsions were analyzed through the evaluation of stability over time, pH, zeta potential, and particle size distribution analysis. Moreover, a design of experiments was performed to assess the most suitable composition based on particle size and stability parameters. The prepared nanoemulsions

SUBMITTER: Schreiner TB 

PROVIDER: S-EPMC7181021 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature