Flame-Made Calcium Phosphate Nanoparticles with High Drug Loading for Delivery of Biologics.

ABSTRACT: Nanoparticles exhibit potential as drug carriers in biomedicine due to their high surface-to-volume ratio that allows for facile drug loading. Nanosized drug delivery systems have been proposed for the delivery of biologics facilitating their transport across epithelial layers and maintaining their stability against proteolytic degradation. Here, we capitalize on a nanomanufacturing process famous for its scalability and reproducibility, flame spray pyrolysis, and produce calcium phosphate (CaP) nanoparticles with tailored properties. The as-prepared nanoparticles are loaded with bovine serum albumin (model protein) and bradykinin (model peptide) by physisorption and the physicochemical parameters influencing their loading capacity are investigated. Furthermore, we implement the developed

SUBMITTER: Tsikourkitoudi V 

PROVIDER: S-EPMC7181047 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature