What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review.

ABSTRACT: Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic using computational fluid dynamics (CFD), limited progress has been made towards understanding the complex physics and biology underlying IA pathophysiology. Guided by 1733 published papers, we review and discuss the contemporary IA hemodynamics paradigm established through two decades of IA CFD simulations. We have traced the historical origins of simplified CFD models which impede the progress of comprehending IA pathology. We also delve into the debate concerning the Newtonian fluid assumption used to represent blood flow computationally. We evidently demonstrate that the Newtonian assumption, used in almost 90% of studies, might be insufficient to describe IA hemodynamics. In addition, some fundamenta

SUBMITTER: Saqr KM 

PROVIDER: S-EPMC7181089 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature