Anti-Estrogenic Activity of Guajadial Fraction, from Guava Leaves (Psidium guajava L.).

ABSTRACT: The research of natural products has allowed for the discovery of biologically relevant compounds inspired by plant secondary metabolites, which contributes to the development of many chemotherapeutic drugs used in cancer treatment. Psidium guajava leaves present a diverse phytochemical composition including flavonoids, phenolics, meroterpenoids, and triterpenes as the major bioactive constituents. Guajadial, a caryophyllene-based meroterpenoid, has been studied for potential anticancer effects tested in tumor cells and animal experimental models. Moreover, guajadial has been reported to have a mechanism of action similar to tamoxifen, suggesting this compound as a promisor phytoestrogen-based therapeutic agent. Herein, the anti-estrogenic action and anti-proliferative activity of guajadia

SUBMITTER: Bazioli JM 

PROVIDER: S-EPMC7181212 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature