Air pollution exposure is associated with the gut microbiome as revealed by shotgun metagenomic sequencing.

ABSTRACT: Animal work indicates exposure to air pollutants may alter the composition of the gut microbiota. This study examined relationships between air pollutants and the gut microbiome in young adults residing in Southern California. Our results demonstrate significant associations between exposure to air pollutants and the composition of the gut microbiome using whole-genome sequencing. Higher exposure to 24-hour O₃ was associated with lower Shannon diversity index, higher Bacteroides caecimuris, and multiple gene pathways, including L-ornithine de novo biosynthesis as well as pantothenate and coenzyme A biosynthesis I. Among other pollutants, higher NO₂ exposure was associated with fewer taxa, including higher Firmicutes. The percent variation in gut bacterial composition

SUBMITTER: Fouladi F 

PROVIDER: S-EPMC7181344 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature