Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.

ABSTRACT: Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the lesion microenvironment of older subjects contribute to this decline. Microglia and monocyte-derived macrophages are critical for successful remyelination, releasing growth factors and clearing inhibitory myelin debris. Several studies have implicated delayed recruitment of macrophages/microglia into lesions as a key contributor to the decline in remyelination observed in older subjects. Here we show that the decreased expression of the scavenger receptor CD36 of aging mouse microglia and human microglia in culture underlies their reduced pha

SUBMITTER: Rawji KS 

PROVIDER: S-EPMC7181452 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature