The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D.

ABSTRACT: Evidence suggests vitamin D has preventive potential in asthma; however, not all children benefit from this intervention. This study aimed to investigate whether variation in the functional 17q21 single nucleotide polymorphism rs12936231 affects the preventive potential of vitamin D against asthma.A combined secondary analysis of two randomised controlled trials of prenatal vitamin D supplementation for the prevention of asthma in offspring (Vitamin D Antenatal Asthma Reduction Trial (VDAART) and Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC₂₀₁₀)) was performed, stratifying by genotype and integrating metabolite data to explore underlying mechanisms.The protective effect of vitamin D on asthma/wheeze was evident among children with the low-risk rs12936231 GG

SUBMITTER: Kelly RS 

PROVIDER: S-EPMC7181456 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature