Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats.

ABSTRACT:

Background

As subarachnoid hemorrhage due to rupture of an intracranial aneurysm (IA) has quite a poor outcome despite of an intensive medical care, development of a novel treatment targeting unruptured IAs based on the correct understanding of pathogenesis is mandatory for social health.

Methods

Using previously obtained gene expression profile data from surgically resected unruptured human IA lesions, we selected G-protein coupled receptor 120 (GPR120) as a gene whose expression is significantly higher in lesions than that in control arterial walls. To corroborate a contribution of GPR120 signaling to the pathophysiology, we used an animal model of IAs and examine the effect of a GPR120 agonist on the progression of the disease. IA lesion was induced in rats through an inc

SUBMITTER: Abekura Y 

PROVIDER: S-EPMC7181479 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature