IL-33, diet-induced obesity, and pulmonary responses to ozone.

ABSTRACT:

Background

Obesity augments pulmonary responses to ozone. We have reported that IL-33 contributes to these effects of obesity in db/db mice. The purpose of this study was to determine whether IL-33 also contributes to obesity-related changes in the response to ozone in mice with diet-induced obesity.

Methods

Male wildtype C57BL/6 mice and mice deficient in ST2, the IL-33 receptor, were placed on chow or high fat diets for 12 weeks from weaning. Because the microbiome has been implicated in obesity-related changes in the pulmonary response to ozone, mice were either housed with other mice of the same genotype (same housed) or with mice of the opposite genotype (cohoused). Cohousing transfers the gut microbiome from one mouse to its cagemates.

Results

Diet-induced incre

SUBMITTER: Kasahara DI 

PROVIDER: S-EPMC7181525 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature