T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease.

ABSTRACT: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by abnormal accumulation of alpha-synuclein (α-syn) in oligodendrocytes accompanied by inflammation, demyelination, and subsequent synapse and neuronal loss. Little is known about the mechanisms of neurodegeneration in MSA. However, recent work has highlighted the important role of the immune system to the pathophysiology of other synuclein-related diseases such as Parkinson's disease. In this study, we investigated postmortem brain tissue from MSA patients and control subjects for evidence of immune activation in the brain. We found a significant increase of HLA-DR⁺ microglia in the putamen and substantia nigra of MSA patient tissue compared to controls, as well as significant increases in C

SUBMITTER: Williams GP 

PROVIDER: S-EPMC7181566 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature