Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources.

ABSTRACT: Brain networks are spatiotemporal phenomena that dynamically vary over time. Functional imaging approaches strive to noninvasively estimate these underlying processes. Here, we propose a novel source imaging approach that uses high-density EEG recordings to map brain networks. This approach objectively addresses the long-standing limitations of conventional source imaging techniques, namely, difficulty in objectively estimating the spatial extent, as well as the temporal evolution of underlying brain sources. We validate our approach by directly comparing source imaging results with the intracranial EEG (iEEG) findings and surgical resection outcomes in a cohort of 36 patients with focal epilepsy. To this end, we analyzed a total of 1,027 spikes and 86 seizures. We demonstrate the capabili

SUBMITTER: Sohrabpour A 

PROVIDER: S-EPMC7181775 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature