Endogenous and exogenous control of visuospatial selective attention in freely behaving mice.

ABSTRACT: Visuospatial selective attention has been investigated primarily in head-fixed animals and almost exclusively in primates. Here, we develop two human-inspired, discrimination-based behavioral paradigms for studying selective visuospatial attention in freely behaving mice. In the 'spatial probability' task, we find enhanced accuracy, sensitivity, and rate of evidence accumulation at the location with higher probability of target occurrence, and opposite effects at the lower probability location. Together with video-based 3D head-tracking, these results demonstrate endogenous expectation-driven shifts of spatial attention. In the 'flanker' task, we find that a second stimulus presented with the target, but with conflicting information, causes switch-like decrements in accuracy and sensitivit

SUBMITTER: You WK 

PROVIDER: S-EPMC7181831 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature