Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum.

ABSTRACT: Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) in the dorsal striatum (DS) and the nucleus accumbens (Acb) jointly but differentially contribute to the fine regulation of movement. However, their region-specific molecular features are presently unknown. By combining RNAseq of striatal D2R neurons and histological analyses, we identified hundreds of novel region-specific molecular markers, which may serve as tools to target selective subpopulations. As a proof of concept, we characterized the molecular identity of a subcircuit defined by WFS1 neurons and evaluated multiple behavioral tasks after its temporally-controlled deletion of D2R. Consequently, conditional D2R knockout mice di

SUBMITTER: Puighermanal E 

PROVIDER: S-EPMC7181842 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature