Ontology highlight
ABSTRACT:
SUBMITTER: Seo JA
PROVIDER: S-EPMC7181874 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200424 1
Crosstalk between liver and skeletal muscle is vital for glucose homeostasis. Hepatokines, liver-derived proteins that play an important role in regulating muscle metabolism, are important to this communication. Here we identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a low-density lipoprotein receptor-related protein-2 (LRP2)-dependent mechanism, coupled with the insulin receptor (IR) signaling cascade. In muscle, LRP2 is ...[more]