Quantitative Modeling Extends the Antibacterial Activity of Nitric Oxide.

ABSTRACT: Numerous materials have been developed to try and harness the antimicrobial properties of nitric oxide (NO). However, the short half-life and reactivity of NO have made precise, tunable delivery difficult. As such, conventional methodologies have generally relied on donors that spontaneously release NO at different rates, and delivery profiles have largely been constrained to decaying dynamics. In recent years, the possibility of finely controlling NO release, for instance with light, has become achievable and this raises the question of how delivery dynamics influence therapeutic potential. Here we investigated this relationship using Escherichia coli as a model organism and an approach that incorporated both experimentation and mathematical modeling. We found that the best performing del

SUBMITTER: Sivaloganathan DM 

PROVIDER: S-EPMC7181900 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature