T-Cell based therapies for overcoming neuroanatomical and immunosuppressive challenges within the glioma microenvironment.

ABSTRACT: Glioblastoma remains as the most common and aggressive primary adult brain tumor to date. Within the last decade, cancer immunotherapy surfaced as a broadly successful therapeutic approach for a variety of cancers. However, due to the neuroanatomical and immunosuppressive nature of malignant gliomas, conventional chemotherapy and radiotherapy treatments garner limited efficacy in patients with these tumors. The intricate structure of the blood brain barrier restricts immune accessibility into the tumor microenvironment, and malignant gliomas can activate various adaptive responses to subvert anticancer immune responses and reinstate an immunosuppressive milieu. Yet, evidence of lymphocyte infiltration within the brain and recent advancements made in cell engineering technologies implicate

SUBMITTER: Kwok D 

PROVIDER: S-EPMC7182069 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature