A molecular odorant transduction model and the complexity of spatio-temporal encoding in the Drosophila antenna.

ABSTRACT: Over the past two decades, substantial amount of work has been conducted to characterize different odorant receptors, neuroanatomy and odorant response properties of the early olfactory system of Drosophila melanogaster. Yet many odorant receptors remain only partially characterized, and the odorant transduction process and the axon hillock spiking mechanism of the olfactory sensory neurons (OSNs) have yet to be fully determined. Identity and concentration, two key characteristics of the space of odorants, are encoded by the odorant transduction process. Detailed molecular models of the odorant transduction process are, however, scarce for fruit flies. To address these challenges we advance a comprehensive model of fruit fly OSNs as a cascade consisting of an odorant transduction process (

SUBMITTER: Lazar AA 

PROVIDER: S-EPMC7182276 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature