Keth-seq for transcriptome-wide RNA structure mapping.

ABSTRACT: RNA secondary structure is critical to RNA regulation and function. We report a new N₃-kethoxal reagent that allows fast and reversible labeling of single-stranded guanine bases in live cells. This N₃-kethoxal-based chemistry allows efficient RNA labeling under mild conditions and transcriptome-wide RNA secondary structure mapping.

SUBMITTER: Weng X 

PROVIDER: S-EPMC7182492 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature