The rhythm and rate of distension-induced esophageal contractility: A physiomarker of esophageal function.

ABSTRACT:

Background

Distention of the esophagus elicits a unique pattern of repetitive contractions in healthy controls. We aimed to assess the rhythm and rate of distension-induced contractile patterns between achalasia and controls and identify factors that distinguish the normal contractile response to distension.

Methods

Twenty asymptomatic controls and 140 adult patients with treatment-naïve achalasia defined by HRM (29 type I, 81 type II, 30 type III) were prospectively evaluated with functional luminal imaging probe (FLIP) during sedated endoscopy. 16-cm FLIP balloons were positioned within the distal esophagus during stepwise balloon distension. Functional luminal imaging probe panometry studies were retrospectively analyzed using a customized program.

Key results

All

SUBMITTER: Carlson DA 

PROVIDER: S-EPMC7182495 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature