Toward unified molecular surveillance of RSV: A proposal for genotype definition.

ABSTRACT:

Background

Human respiratory syncytial virus (RSV) is classified into antigenic subgroups A and B. Thirteen genotypes have been defined for RSV-A and 20 for RSV-B, without any consensus on genotype definition.

Methods

We evaluated clustering of RSV sequences published in GenBank until February 2018 to define genotypes by using maximum likelihood and Bayesian phylogenetic analyses and average p-distances.

Results

We compared the patterns of sequence clustering of complete genomes; the three surface glycoproteins genes (SH, G, and F, single and concatenated); the ectodomain and the 2nd hypervariable region of G gene. Although complete genome analysis achieved the best resolution, the F, G, and G-ectodomain phylogenies showed similar topologies with statistical support c

SUBMITTER: Goya S 

PROVIDER: S-EPMC7182609 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature