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Biodiscovery of antibacterial constituents from the endolichenic fungi isolated from Parmotrema rampoddense.

ABSTRACT: A total of nine endolichenic fungi were isolated from the foliose lichen Parmotrema rampoddense (Nyl.) Hale. Of the nine endolichenic fungi, three taxa (Fusarium proliferatum, Nemania primolutea, Daldinia eschsholtzii) showed antibacterial activities as determined by the disk diffusion assay against ESKAPE bacterial pathogens. Fusarium proliferatum gave the most active fungal extract with zone of inhibition values of 15 mm and 19 mm against E. faecalis and S. aureus, respectively. Further chromatographic purification of the F. proliferatum ethyl acetate extract led to the isolation and identification of bis(2-ethylhexyl)terephthalate (1), acetyl tributyl citrate (2), and fusarubin (3). Acetyl tributyl citrate (2) exhibited moderate antibacterial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus.

SUBMITTER: Tan MA

PROVIDER: S-EPMC7182646 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Biodiscovery of antibacterial constituents from the endolichenic fungi isolated from Parmotrema rampoddense.

Tan Mario A MA Castro Sarleen G SG Oliva Patricia Marie P PMP Yap Paul Raymund J PRJ Nakayama Atsushi A Magpantay Hilbert D HD Dela Cruz Thomas Edison E TEE

3 Biotech 20200424 5

A total of nine endolichenic fungi were isolated from the foliose lichen Parmotrema rampoddense (Nyl.) Hale. Of the nine endolichenic fungi, three taxa (Fusarium proliferatum, Nemania primolutea, Daldinia eschsholtzii) showed antibacterial activities as determined by the disk diffusion assay against ESKAPE bacterial pathogens. Fusarium proliferatum gave the most active fungal extract with zone of inhibition values of 15 mm and 19 mm against E. faecalis a ...[more]

PMID: 32351870

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